playing binding of isaac first time

rebirth. any tips? haven't played the og

friend of mine is autistically obsessed with that game but idk anything about it so i am contributing nothing to this conversation

take devil room items so you can unlock azael, he is the strongest early game character you can unlock. You get devil room items by clearing rooms without taking a hit. This counts for every room besides the very first starting room where it doesnt matter if you get hit or not because you wont get a devil room anyways

idk never played

just keep playing and finding stuff yourself before you explore mods. the one I might recommend is the item description one cause the amount of stuff you find in the beginning can be overwhelming