Personally, I just think that there should be a league dedicated only to females, and one that is dedicated to the "marginalized genders" within the community as per the whole idea behind game changers to begin with. I say this because I don't see any transmen playing in any GC team. To handicap females against males in a male-dominated sphere is pretty much counter productive to the very thing they are trying to achieve. It's ironic to say the least.
Edit: I also want to highlight that one of the most common ways to this realization is thinking about how less transwomen are compared to females in this world, and yet they are dominating the charts in the league. How and why does that work?