Last year, when Fnatic were not able to get Derke and Braveaf to Iceland, they could get 2 other players to the roster as substitutes.
I don't know about Franchising substitute rules, but with things like Roster Lock existing what can teams without a 6th man do in case someone feels sick or doesn't get a Visa for an international tourney? KC are about to let their assistant coach play on the main team because they don't have a proper 6th man. Can you bring someone else instead of the 6th man to Masters Tokyo incase someone on a team does not get a Visa?