I think its the best case if Riot will divide the region like Valve with their DotA, but it's different like:
Asia: APAC, KRJP(or maybe China will join this region), and SA. or dividing into only 2 regions, West Asia and East Asia
Europe: It's better to divide into only 2 regions, West Europe and East Europe
America: same as Europe, North America, and South America. or only 1 region