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Liquid dosage forms are usually more susceptible to chemical degradation when compared to solid dosage forms.
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They are bulky and therefore inconvenient to transport and store.
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Accidental breakage of the container results in loss of whole dosage form.
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The shelf-life of a liquid dosage form is often much shorter than that of the corresponding solid preparation due to low stability.
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Solution often provides suitable media for microbial growth and may, therefore, require the incorporation of a preservative.
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Liquid dosage forms e.g., vaccines may require special storage conditions
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The taste of a drug which is usually unpleasant is always more prominent when in solution than in a solid form.
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There is a higher chance of dose variability since the delivery of the dose depends upon the patient measuring the proper volume. This can be significant issue for vision-impaired patients, patients with arthritis, or patients unable to read the numbers on an oral dosing syringe or medicine cup.