Regional league? I'm not sure viewership is interested in another franchise league with same orgs over and over, and people comes from a tournaments open circuit (CSGO) so it would be boring for them, also a league can have like 10 teams or around, there are too many orgs there. Current circuit Challengers-Masters-Champions? It's not profitable for tier 2 orgs or even tier 3 orgs, and it would suck if they leave. Open circuit? There is no ESEA tournaments there for example, just NSG and it's not enough for a whole year, also IEM, Blast, etc are all on Europe and that would force them to play in EU that it's the same problem than NA CSGO players have right now, and even if you go for open circuit, some asian scenes would die because all they have is VCT circuit.
I think this is a serious problem and noone it's talking about it.