Currently speaking, the top two regions are NA and APAC. This based on the Alpha Bracket of the LOCK//IN event. Looking at the stats, NA and APAC are currently the top two considering only these two regions were able to get past the first round, where NRG and LOUD became the best for the Americas, and DRX and Talon became the best for the Pacific. Even now, in the Omega Bracket, Team Secret from APAC has already eliminated Team Liquid, which after its roster changes was looking to be one of the super teams of the event, signing nAts and Redgar from the ex-Gambit/M3C roster, as well as Sayf from Guild eSports, who is a pretty well rounded IGL. Note that Team Secret wasn’t expected to do much, with their last LAN being in Champions 2021. Even then, their most recent performances weren’t as good as hoped, with them losing to DRX and Team heretics. Team Liquid on the other hand, despite not having had a single match with their current roster until now, were still expected to be a super team.
Of course we still have super teams such as NAVI and Fnatic who we can expect good results from, but looking at the massive improvement from APAC as well, I believe this year will belong to mainly the Americas and the Pacific league, instead of EMEA who used to be the powerhouse along with the Americas.